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Omowunmi (Wunmi) Sadik
Professor, Bioanalytical, Materials  & Environmental Chemistry

 

Director, Center for Advanced Sensor Research & Environmental Systems (CASE)


Member, JEM Editorial Board

Principal Investigator, MOPS Database

 

CONTACT INFORMATION:
Department of Chemistry
State University of New York at Binghamton
Binghamton, NY 13902

e-mail: osadik@binghamton.edu
Phone:  (607) 777-4132
Fax:     (607) 777-4478

Lab:     (607) 777-6392

 

PROFESSIONAL BACKGROUND

  • Sabbatical, Harvard University (2003)
  • Senior Visiting Research Fellow, Cornell University, (2002)
  • Visiting Research Scientist, Naval Research Laboratories (2001)
  • NRC Postdoctoral Fellow, US-Environmental Protection Agency
  • Ph.D., University of Wollongong, Australia

  

AWARDS & RECOGNITIONS

RESEARCH INTERESTS

 

Our group is composed of undergraduates, graduates, postdoctoral researchers and visiting scholars. Our research interests lie in the area of Bioanalytical Chemistry, Materials and Environmental Chemistry. In Bioanalytical Chemistry, we are working at the interface between Analytical Chemistry and Molecular Bioelectronics. More specifically, our group employs antibodies, cells, nucleic acids, carbohydrates and enzymes to design new assays and biosensors based on electrochemical, piezoelectric and optical techniques that find application in the biomedical and environmental fields. Additional research focus of our group is in the design of immunoconjugates tandem instrumental techniques, hybrid organic-inorganic polymers and electroless plating.

 

More recently, our group has also focused on the design and fabrication of U-PAC devices involving a biosensor and a completely automated sampling system requiring minimal user interaction.  The current prototype does not require a laptop (although optional) for signal processing and is completely battery powered.  The user must only insert the sample, turn the pump switch on or off and record the data.  The rigid alignment of the sensor components and the integrated closed fluidics system provide a durable setup for field use and can easily be adapted to remote sensing applications. These advanced sensing systems are aimed to provide individually addressable multi sensing elements, to meet the needs of each patient and/or user.

 

Our Group is also studying a series of synthetic and natural phenolic estrogens for their ability to affect the viability and proliferation of lung cancer cells. To assess and distinguish the cytotoxic effect of individual estrogens we are using both MTT tetrazolium spectrophotometric method and Fluorescence assay, while the induction of the cell-specific apoptotic process is being examined by fluorescence microscopy after treatment of cells with fluorescent dyes. A systematic study of interferences for both Fluorescence and MTT methods showed that both natural and synthetic estrogens decreased the viability and proliferation of A549 lung cancer cells in a dose dependent manner, but at different sensitivities. Nonylphenol appeared very different compared to the other estrogens, acting by inducing the higher inactivation rate of the cells within a very short time. Cytotoxic effect of the estrogens is being directly related to their structural and conformational characteristics including chain length, number and position of hydroxyl groups and degree of saturation.

 

SELECTED PUBLICATIONS

Summary: 100+ Peer-reviewed research articles, 12 patents/patent applications, 300+ presentations, 14 Workshops and Symposia.

Recent Publications (mostly 2004 – 2007)

  • Sadik O. A. Yan F., Electrochemical Biosensors for Monitoring the Recognition of Glycoprotein-Lectins Interactions, Analytical Chimica Acta, 588, 292-296, 2007.
  • Omole M., Kowino I., Sadik O. A., “Palladium Nanoparticles for Catalytic Reduction of Cr (VI) using Formic Acid” Catalysis B: Environmental, (In Press) 2007.
  • Sadik O., Kikandi S., “Electroless Deposition of Titanium onto Aluminum Substrates,” Journal of Electrochemical Society, 2007 (In Press).
  • Kowino I., Omole M., Sadik O. A., Novel Palladium Nanoparticles-sulfur Mixture as Environmental Catalyst for the Rapid Conversion of Cr (VI) to Cr (III), Journal of Environmental Monitoring, 2007 (In Press).
  • Silvana Andreescu, Jason Karasinski, Omowunmi A. Sadik, Multiarray Biosensors for Toxicity Monitoring and Bacterial Pathogens, In: Smart Biosensors, Knopf G. K., Bassi A. S. Editors, CRC Press, USA, pp 521-538, 2007.
  • Wanekaya A. Sadik O.A., Development of Tandem Chromatography Sensor Arrays Technologies, Encyclopedia of Sensors, Edited by Graig A. Grimes, Elizabeth C. Dickey, Miachael V. Pishko, Volume 2, Pages 333-347, 2006, American Scientific Publishers.
  • Andreescu S. Karasinski J., Sadik O.A., High-throughput Biosensor Systems for Monitoring Cells and Bacteria, Encyclopedia of Sensors, Edited by Graig A. Grimes, Elizabeth C. Dickey, Michael V. Pishko, Volume 4, pages 459-480, 2006, American Scientific Publishers.
  • Jason Karasinski, Silvana Andreescu, Leslie White, Yachao Zhang and Omowunmi A. Sadik, Barry K. Lavine and Mehul Vora, Detection and Identification of Bacteria using Antibiotic Susceptibility and a Multiarray Electrochemical Sensor with Pattern Recognition, Biosensors & Bioelectronics, 2006 (In Press).
  • Omole M., Aluoch A., Sadik O. A., “Environmental and Bioanalytical Applications of Metal Nanoparticles, ”In Handbook of Electrochemical Nanotechnology, American Scientific Publishers, (2006). (In Press).
  • Fatah A., Arcilesi R., Chekol T., Sadik O. A., Aluoch A., "Guide for the Selection of Biological Agent Detection Equipment for First Responders," Guide 101-104, June 2006, Second Edition, Department of Homeland Security, Washington DC.
  • Andreescu, D., Wanekaya A., O.A. Sadik, Wang J., “Nanostructured Polyamic Membranes as Electrode Material,” Langmuir, 21(15), 6891-6899, 2005.
  • Andreescu S., Sadik O. A., McGee N., Effect of natural and synthetic estrogens on A549 lung cancer cells: correlation of chemical structures with cytotoxic effects, Chemical Research in Toxicology, 18 (3): 466-474 MAR 2005.
  • Karasinski J. Andreescu S., Sadik O. A., Lavine B., Multiarray Sensors with Pattern Recognition for the Detection, Classification and Differentiation of Bacteria at Species and Subspecies Levels, Analytical Chemistry, 77/24, 7941-7949, 2005.
  • Aluoch A. Sadik O. A., Gurrinder B., “Development of an Oral Biosensor for Salivary Amylase using a Monodispersed Silver for Signal Amplification,” Analytical Biochemistry, 340 (1): 136-144 MAY 1, 2005.
  • Andreescu D., Sadik O. A., Synthesis of Polyoxydianiline Membranes onto Gold Electrodes: An Electrochemical Study, Journal of Electrochemical Society, 152(10), 152 (10): E299-E307, 2005.
  • Sadik OA, Hongwu Xu, Sargent A., Multielectron Transfer Mechanism of Dimethylamine Borane in Electroless Gold Deposition, Journal of Electroanalytical Chemistry, Vol 583, Issue 2, pp 167-175, 2005.
  • Karasinski J., Andreescu S., Sadik O., A., Biosensors Edited by Avraham Rasooly, “Advanced Electrochemical Sensors for Cell Cancer Monitoring,” Methods, 37, Issue 1, pp 84-93, 2005,
  • Andreescu, D., S. Andreescu, O.A. Sadik, New Materials for Biosensors, Biochips and Molecular Bioelectronics (A review- Invited contribution) in  “Comprehensive Analytical Chemistry”, Edited by L. Gorton, Elsevier, Volume 44, pp 285-327, 2005.
  • Aluoch A. Sadik O. A., Amrute K., “Novel Electrochemical Oral Biosensors for Histatin, Sensor Letters, Vol 3, No.2, pp 161-163, 2005.
  • Andreescu S., Sadik OA., “Correlation of Analyte Structures with Biosensor Responses using the Detection of Phenolic Estrogens as a Model Example,” Analytical Chemistry, 76 (3) 552-560, 2004.
  • Sadik O. A., Yan F., “Novel Biosensor for Pathogenic Toxins using Fluorescent Cyclic Polypeptide Conjugate,” Chemical Communications, 1136-1137, 2004.
  • Sadik O. A., Wanekaya A., Walker L., Uematsu M., Wong L, Embrechts M., “Detection and Classification of Organophosphate Nerve Agent Simulants using Support Vector Machines with Multiarray Sensors,” Journal of Chemical Information and Computer Sciences, 44, 499-507, 2004.
  • Andreescu S., Sadik OA, McGee D., “Autonomous Multielectrode System for Monitoring the Interactions of Isoflavonoids with Lung Cancer Cells,” Analytical Chemistry, 76, 2321-2330, 2004.
  • Andreescu S., Sadik OA, “Trends & Challenges in Biochemical Sensors for Clinical and Environmental Monitoring,” Pure and Applied Chemistry, Vol 76, No.4, pp. 861-878, 2004.
  • Sadik O. A., Andreescu S., Wanekaya A., “Advanced Environmental Methodologies for Agent Detection, Journal of Environmental Monitoring, 6,513-522, 2004 (A Royal Society of Chemistry Hot Article).
  • Andreescu S., Sadik OA., “Correlation of Analyte Structures with Biosensor Responses using the Detection of Phenolic Estrogens as a Model Example,” Analytical Chemistry, 76 (3) 552-560, 2004.
  • Sadik O. A., Yan F., “Novel Biosensor for Pathogenic Toxins using Fluorescent Cyclic Polypeptide Conjugate,” Chemical Communications, 1136-1137, 2004.
  •  Sadik O. A., Wanekaya A., Walker L., Uematsu M., Wong L, Embrechts M., “Detection and Classification of Organophosphate Nerve Agent Simulants using Support Vector Machines with Multiarray Sensors,” Journal of Chemical Information and Computer Sciences, 44, 499-507, 2004.
  • Andreescu S., Sadik O. A, McGee D., “Autonomous Multielectrode System for Monitoring the Interactions of Isoflavonoids with Lung Cancer Cells,” Analytical Chemistry, 76, 2321-2330, 2004.
  • Sadik O. A., Wanekaya A., “PACE: A Novel Tool for Teaching Sample Preparation Techniques in Undergraduate Laboratory,” J. Chemical Education, 81(8), 1177-1181, 2004.
  • Aluoch A., Tatini R., Sadik, O. A,  “Stability Indicating Ion-Pair HPLC for Determining Bisphosphonates in a Commercial Formulation,” Journal of Liquid Chromatography 27(No17), 2799, 2004.

 

 

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